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Mechanistic Studies of Inactivation of Inducible Nitric Oxide Synthase by Amidines

Nitric oxide synthase (NOS) catalyzes the conversion of l-arginine to l-citrulline and nitric oxide. N(5)-(1-Iminoethyl)-L-ornithine (L-NIO), an amidine-containing molecule, is a natural product known to be an inactivator of inducible NOS (iNOS). Because of the presence of the amidine methyl group i...

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Pubblicato in:Biochemistry
Autori principali: Tang, Wei, Li, Huiying, Poulos, Thomas L., Silverman, Richard B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4410366/
https://ncbi.nlm.nih.gov/pubmed/25811913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00135
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