LPS exacerbates functional and inflammatory responses to ovalbumin and decreases sensitivity to inhaled fluticasone propionate in a guinea pig model of asthma

BACKGROUND AND PURPOSE: Asthma exacerbations contribute to corticosteroid insensitivity. LPS is ubiquitous in the environment. It causes bronchoconstriction and airway inflammation and may therefore exacerbate allergen responses. This study examined whether LPS and ovalbumin co-administration could...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Lowe, A P P, Thomas, R S, Nials, A T, Kidd, E J, Broadley, K J, Ford, W R
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4409909/
https://ncbi.nlm.nih.gov/pubmed/25586266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13080
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