LPS exacerbates functional and inflammatory responses to ovalbumin and decreases sensitivity to inhaled fluticasone propionate in a guinea pig model of asthma

BACKGROUND AND PURPOSE: Asthma exacerbations contribute to corticosteroid insensitivity. LPS is ubiquitous in the environment. It causes bronchoconstriction and airway inflammation and may therefore exacerbate allergen responses. This study examined whether LPS and ovalbumin co-administration could...

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Dades bibliogràfiques
Publicat a:Br J Pharmacol
Autors principals: Lowe, A P P, Thomas, R S, Nials, A T, Kidd, E J, Broadley, K J, Ford, W R
Format: Artigo
Idioma:Inglês
Publicat: BlackWell Publishing Ltd 2015
Matèries:
Research Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4409909/
https://ncbi.nlm.nih.gov/pubmed/25586266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13080
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