GPCR dimerization in brainstem nuclei contributes to the development of hypertension

BACKGROUND AND PURPOSE: μ-Opioid receptors, pro-opiomelanocortin and pro-enkephalin are highly expressed in the nucleus tractus solitarii (NTS) and μ receptor agonists given to the NTS dose-dependently increased BP. However, the molecular mechanisms of this process remain unclear. In vitro, μ recept...

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Bibliographische Detailangaben
Veröffentlicht in:Br J Pharmacol
Hauptverfasser: Sun, Gwo-Ching, Ho, Wen-Yu, Chen, Bo-Rung, Cheng, Pei-Wen, Cheng, Wen-Han, Hsu, Mei-Chi, Yeh, Tung-Chen, Hsiao, Michael, Lu, Pei-Jung, Tseng, Ching-Jiunn
Format: Artigo
Sprache:Inglês
Veröffentlicht: BlackWell Publishing Ltd 2015
Schlagworte:
Research Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4409903/
https://ncbi.nlm.nih.gov/pubmed/25573074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13074
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