GPCR-mediated EGF receptor transactivation regulates TRPV4 action in the vasculature

BACKGROUND AND PURPOSE: Transient receptor potential vanilloid-4 (TRPV4) is a calcium-permeant ion channel that is known to affect vascular function. The ability of TRPV4 to cause a vasoconstriction in blood vessels has not yet been mechanistically examined. Further in neuronal cells, TRPV4 signalli...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Saifeddine, Mahmoud, El-Daly, Mahmoud, Mihara, Koichiro, Bunnett, Nigel W, McIntyre, Peter, Altier, Christophe, Hollenberg, Morley D, Ramachandran, Rithwik
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4409902/
https://ncbi.nlm.nih.gov/pubmed/25572823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13072
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