Potential antitumor therapeutic application of Grimontia hollisae thermostable direct hemolysin mutants

We report on the preparation of a new type of immunotoxin by conjugation of an epidermal growth factor receptor (EGFR)-binding peptide and an R46E mutation of thermostable direct hemolysin from Grimontia hollisae, (Gh-TDH(R)(46E)/EB). The hybrid immunotoxin was purified to homogeneity and showed a s...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Cancer Sci
Main Authors: Huang, Sheng-Cih, Wang, Yu-Kuo, Huang, Wan-Ting, Kuo, Tsam-Ming, Yip, Bak-Sau, Li, Tien-Hsiung Thomas, Wu, Tung-Kung
Format: Artigo
Jezik:Inglês
Izdano: BlackWell Publishing Ltd 2015
Teme:
Original Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4409889/
https://ncbi.nlm.nih.gov/pubmed/25640743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12623
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