Hydrogen/Deuterium Exchange Mass Spectrometry Applied to IL-23 Interaction Characteristics: Potential Impact for Therapeutics

Interleukin-23 (IL-23) is an important therapeutic target for the treatment of inflammatory diseases. Adnectins are targeted protein therapeutics that are derived from domain III of human fibronectin, and have similar protein scaffold to antibodies. A specific adnectin (Adnectin 2) was identified to...

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Pubblicato in:Expert Rev Proteomics
Autori principali: Iacob, Roxana E., Krystek, Stanley R., Huang, Richard Y.-C., Wei, Hui, Tao, Li, Lin, Zheng, Morin, Paul E., Doyle, Michael L., Tymiak, Adrienne A., Engen, John R., Chen, Guodong
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4409866/
https://ncbi.nlm.nih.gov/pubmed/25711416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1586/14789450.2015.1018897
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