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Asymmetric Unwrapping of Nucleosomes under Tension Directed by DNA Local Flexibility
Dynamics of the nucleosome and exposure of nucleosomal DNA play key roles in many nuclear processes but local dynamics of the nucleosome and its modulation by DNA sequence are poorly understood. Using single-molecule assays we observed that the nucleosome can unwrap asymmetrically and directionally...
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| Veröffentlicht in: | Cell |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4409768/ https://ncbi.nlm.nih.gov/pubmed/25768909 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.02.001 |
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