Chemoresistance is associated with increased cytoprotective autophagy and diminished apoptosis in bladder cancer cells treated with the BH3 mimetic (−)-Gossypol (AT-101)

BACKGROUND: Acquired resistance to standard chemotherapy causes treatment failure in patients with metastatic bladder cancer. Overexpression of pro-survival Bcl-2 family proteins has been associated with a poor chemotherapeutic response, suggesting that Bcl-2-targeted therapy may be a feasible strat...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Mani, Jens, Vallo, Stefan, Rakel, Stefanie, Antonietti, Patrick, Gessler, Florian, Blaheta, Roman, Bartsch, Georg, Michaelis, Martin, Cinatl, Jindrich, Haferkamp, Axel, Kögel, Donat
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4409725/
https://ncbi.nlm.nih.gov/pubmed/25885284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1239-4
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