C9orf72 promoter hypermethylation is neuroprotective: Neuroimaging and neuropathologic evidence

OBJECTIVE: To use in vivo neuroimaging and postmortem neuropathologic analysis in C9orf72 repeat expansion patients to investigate the hypothesis that C9orf72 promoter hypermethylation is neuroprotective and regionally selective. METHODS: Twenty patients with a C9orf72 repeat expansion participating...

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Bibliografski detalji
Izdano u:Neurology
Glavni autori: McMillan, Corey T., Russ, Jenny, Wood, Elisabeth M., Irwin, David J., Grossman, Murray, McCluskey, Leo, Elman, Lauren, Van Deerlin, Vivanna, Lee, Edward B.
Format: Artigo
Jezik:Inglês
Izdano: Lippincott Williams & Wilkins 2015
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4409587/
https://ncbi.nlm.nih.gov/pubmed/25795648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0000000000001495
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