טוען...
C9orf72 hypermethylation protects against repeat expansion-associated pathology in ALS/FTD
Hexanucleotide repeat expansions of C9orf72 are the most common genetic cause of amyotrophic lateral sclerosis and frontotemporal degeneration. The mutation is associated with reduced C9orf72 expression and the accumulation of potentially toxic RNA and protein aggregates. CpG methylation is known to...
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| Main Authors: | , , , , , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2014
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4161616/ https://ncbi.nlm.nih.gov/pubmed/24806409 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-014-1286-y |
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