Plasma Is the Physiologic Buffer of tPA Mediated Fibrinolysis: Rationale for Plasma First Resuscitation after Life-Threatening Hemorrhage

BACKGROUND: Pre-hospital resuscitation with crystalloid exacerbates fibrinolysis, which is associated with high mortality. We hypothesize that plasma compared to crystalloid resuscitation prevents hyperfibrinolysis in a tissue plasminogen activator (tPA) rich environment via preservation of proteins...

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Veröffentlicht in:J Am Coll Surg
Hauptverfasser: Moore, Hunter B, Moore, Ernest E, Gonzalez, Eduardo, Wiener, Gregory, Chapman, Michael P, Dzieciatkowska, Monika, Sauaia, Angela, Banerjee, Anirban, Hansen, Kirk C, Silliman, Christopher
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4409505/
https://ncbi.nlm.nih.gov/pubmed/25840538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jamcollsurg.2015.01.026
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