Mitochondrial DNA Stress Primes the Antiviral Innate Immune Response

Mitochondrial DNA (mtDNA) is normally present at thousands of copies per cell and is packaged into several hundred higher-order structures termed nucleoids(1). The abundant mtDNA-binding protein, transcription factor A mitochondrial (TFAM), regulates nucleoid architecture, abundance, and segregation...

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Pubblicato in:Nature
Autori principali: West, A. Phillip, Khoury-Hanold, William, Staron, Matthew, Tal, Michal C., Pineda, Cristiana M., Lang, Sabine M., Bestwick, Megan, Duguay, Brett A., Raimundo, Nuno, MacDuff, Donna A., Kaech, Susan M., Smiley, James R., Means, Robert E., Iwasaki, Akiko, Shadel, Gerald S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4409480/
https://ncbi.nlm.nih.gov/pubmed/25642965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14156
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