Mitochondrial DNA Stress Primes the Antiviral Innate Immune Response

Mitochondrial DNA (mtDNA) is normally present at thousands of copies per cell and is packaged into several hundred higher-order structures termed nucleoids(1). The abundant mtDNA-binding protein, transcription factor A mitochondrial (TFAM), regulates nucleoid architecture, abundance, and segregation...

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Publicado en:Nature
Main Authors: West, A. Phillip, Khoury-Hanold, William, Staron, Matthew, Tal, Michal C., Pineda, Cristiana M., Lang, Sabine M., Bestwick, Megan, Duguay, Brett A., Raimundo, Nuno, MacDuff, Donna A., Kaech, Susan M., Smiley, James R., Means, Robert E., Iwasaki, Akiko, Shadel, Gerald S.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4409480/
https://ncbi.nlm.nih.gov/pubmed/25642965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14156
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