IL-6 blockade by monoclonal antibodies inhibits apolipoprotein (a) expression and lipoprotein (a) synthesis in humans

Lipoprotein (a) [Lp(a)] is a highly atherogenic lipid particle. Although earlier reports suggested that Lp(a) levels are mostly determined by genetic factors, several recent studies have revealed that Lp(a) induction is also caused by chronic inflammation. Therefore, we aimed to examine whether cyto...

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Detalles Bibliográficos
Publicado en:J Lipid Res
Autores principales: Müller, Nike, Schulte, Dominik M., Türk, Kathrin, Freitag-Wolf, Sandra, Hampe, Jochen, Zeuner, Rainald, Schröder, Johann O., Gouni-Berthold, Ioanna, Berthold, Heiner K., Krone, Wilhelm, Rose-John, Stefan, Schreiber, Stefan, Laudes, Matthias
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Biochemistry and Molecular Biology 2015
Materias:
Patient-Oriented and Epidemiological Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4409280/
https://ncbi.nlm.nih.gov/pubmed/25713100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.P052209
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