IL-6 blockade by monoclonal antibodies inhibits apolipoprotein (a) expression and lipoprotein (a) synthesis in humans

Lipoprotein (a) [Lp(a)] is a highly atherogenic lipid particle. Although earlier reports suggested that Lp(a) levels are mostly determined by genetic factors, several recent studies have revealed that Lp(a) induction is also caused by chronic inflammation. Therefore, we aimed to examine whether cyto...

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Bibliografiske detaljer
Udgivet i:J Lipid Res
Main Authors: Müller, Nike, Schulte, Dominik M., Türk, Kathrin, Freitag-Wolf, Sandra, Hampe, Jochen, Zeuner, Rainald, Schröder, Johann O., Gouni-Berthold, Ioanna, Berthold, Heiner K., Krone, Wilhelm, Rose-John, Stefan, Schreiber, Stefan, Laudes, Matthias
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Biochemistry and Molecular Biology 2015
Fag:
Patient-Oriented and Epidemiological Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4409280/
https://ncbi.nlm.nih.gov/pubmed/25713100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.P052209
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