Sirtuin-3 (SIRT3) Protein Attenuates Doxorubicin-induced Oxidative Stress and Improves Mitochondrial Respiration in H9c2 Cardiomyocytes

Doxorubicin (DOX) is a chemotherapeutic agent effective in the treatment of many cancers. However, cardiac dysfunction caused by DOX limits its clinical use. DOX is believed to be harmful to cardiomyocytes by interfering with the mitochondrial phospholipid cardiolipin and causing inefficient electro...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Cheung, Kyle G., Cole, Laura K., Xiang, Bo, Chen, Keyun, Ma, Xiuli, Myal, Yvonne, Hatch, Grant M., Tong, Qiang, Dolinsky, Vernon W.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2015
Teme:
Metabolism
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4409259/
https://ncbi.nlm.nih.gov/pubmed/25759382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.607960
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