G Protein-coupled Receptor Kinases of the GRK4 Protein Subfamily Phosphorylate Inactive G Protein-coupled Receptors (GPCRs)

G protein-coupled receptor (GPCR) kinases (GRKs) play a key role in homologous desensitization of GPCRs. It is widely assumed that most GRKs selectively phosphorylate only active GPCRs. Here, we show that although this seems to be the case for the GRK2/3 subfamily, GRK5/6 effectively phosphorylate i...

Full description

Saved in:
Bibliographic Details
Published in:J Biol Chem
Main Authors: Li, Lingyong, Homan, Kristoff T., Vishnivetskiy, Sergey A., Manglik, Aashish, Tesmer, John J. G., Gurevich, Vsevolod V., Gurevich, Eugenia V.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2015
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4409243/
https://ncbi.nlm.nih.gov/pubmed/25770216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.644773
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items