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Phosphorylation of Sae2 Mediates Forkhead-associated (FHA) Domain-specific Interaction and Regulates Its DNA Repair Function

Saccharomyces cerevisiae Sae2 and its ortholog CtIP in higher eukaryotes have a conserved role in the initial processing of DNA lesions and influencing their subsequent repair pathways. Sae2 is phosphorylated by the ATR/ATM family kinases Mec1 and Tel1 in response to DNA damage. Among the Mec1/Tel1...

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Vydáno v:J Biol Chem
Hlavní autoři: Liang, Jason, Suhandynata, Raymond T., Zhou, Huilin
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4409241/
https://ncbi.nlm.nih.gov/pubmed/25762720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.625293
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