Ubiquitin-specific Peptidase 20 Regulates Rad17 Stability, Checkpoint Kinase 1 Phosphorylation and DNA Repair by Homologous Recombination

Rad17 is a subunit of the Rad9-Hus1-Rad1 clamp loader complex, which is required for Chk1 activation after DNA damage. Rad17 has been shown to be regulated by the ubiquitin-proteasome system. We have identified a deubiquitylase, USP20 that is required for Rad17 protein stability in the steady-state...

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Detalhes bibliográficos
Main Authors: Shanmugam, Ilanchezhian, Abbas, Mohammad, Ayoub, Farhan, Mirabal, Susan, Bsaili, Manal, Caulder, Erin K., Weinstock, David M., Tomkinson, Alan E., Hromas, Robert, Shaheen, Monte
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
DNA and Chromosomes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4132780/
https://ncbi.nlm.nih.gov/pubmed/24923443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.550459
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