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Heregulin negatively regulates transcription of ErbB2/3 receptors via an AKT-mediated pathway
Despite the importance of the ErbB2/3 heterodimer in breast cancer progression, the negative regulation of these receptors is still poorly understood. We demonstrate here for the first time that the ErbB3/4 ligand Heregulin (HRG) reduced both ErbB2 and ErbB3 mRNA and protein levels in human breast c...
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| 出版年: | J Cell Physiol |
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| 主要な著者: | , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4408997/ https://ncbi.nlm.nih.gov/pubmed/24692179 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.24637 |
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