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Heregulin negatively regulates transcription of ErbB2/3 receptors via an AKT-mediated pathway

Despite the importance of the ErbB2/3 heterodimer in breast cancer progression, the negative regulation of these receptors is still poorly understood. We demonstrate here for the first time that the ErbB3/4 ligand Heregulin (HRG) reduced both ErbB2 and ErbB3 mRNA and protein levels in human breast c...

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Xehetasun bibliografikoak
Argitaratua izan da:J Cell Physiol
Egile Nagusiak: Awasthi, Smita, Hamburger, Anne W.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2014
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4408997/
https://ncbi.nlm.nih.gov/pubmed/24692179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.24637
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