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High glucose induces mitochondrial dysfunction independently of protein O-GlcNAcylation

Diabetes is characterized by hyperglycaemia and perturbations in intermediary metabolism. In particular, diabetes can augment flux through accessory pathways of glucose metabolism, such as the hexosamine biosynthetic pathway (HBP), which produces the sugar donor for the β-O-linked-N-acetylglucosamin...

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Dades bibliogràfiques
Publicat a:Biochem J
Autors principals: Dassanayaka, Sujith, Readnower, Ryan D., Salabei, Joshua K., Long, Bethany W., Aird, Allison L., Zheng, Yu-Ting, Muthusamy, Senthilkumar, Facundo, Heberty T., Hill, Bradford G., Jones, Steven P.
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4408906/
https://ncbi.nlm.nih.gov/pubmed/25627821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20141018
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