High glucose induces mitochondrial dysfunction independently of protein O-GlcNAcylation

Diabetes is characterized by hyperglycaemia and perturbations in intermediary metabolism. In particular, diabetes can augment flux through accessory pathways of glucose metabolism, such as the hexosamine biosynthetic pathway (HBP), which produces the sugar donor for the β-O-linked-N-acetylglucosamin...

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Bibliographic Details
Published in:Biochem J
Main Authors: Dassanayaka, Sujith, Readnower, Ryan D., Salabei, Joshua K., Long, Bethany W., Aird, Allison L., Zheng, Yu-Ting, Muthusamy, Senthilkumar, Facundo, Heberty T., Hill, Bradford G., Jones, Steven P.
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4408906/
https://ncbi.nlm.nih.gov/pubmed/25627821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20141018
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