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Role of transporters in the distribution of platinum-based drugs

Platinum derivatives used as chemotherapeutic drugs such as cisplatin and oxaliplatin have a potent antitumor activity. However, severe side effects such as nephro-, oto-, and neurotoxicity are associated with their use. Effects and side effects of platinum-based drugs are in part caused by their tr...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Harrach, Saliha, Ciarimboli, Giuliano
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4408848/
https://ncbi.nlm.nih.gov/pubmed/25964760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2015.00085
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