YM155 potently kills acute lymphoblastic leukemia cells through activation of the DNA damage pathway

BACKGROUND: Novel-targeted therapies are in rapid development for the treatment of acute lymphoblastic leukemia (ALL) to overcome resistance and decrease toxicity. Survivin, a member of the inhibitor of apoptosis gene family and chromosome passenger complex, is critical in a variety of human cancers...

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Veröffentlicht in:J Hematol Oncol
Hauptverfasser: Chang, Bill H, Johnson, Kara, LaTocha, Dorian, Rowley, Joelle S J, Bryant, Jade, Burke, Russell, Smith, Rebecca L, Loriaux, Marc, Müschen, Markus, Mullighan, Charles, Druker, Brian J, Tyner, Jeffrey W
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2015
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4408565/
https://ncbi.nlm.nih.gov/pubmed/25895498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-015-0132-6
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