Differential DNA methylation profiles of coding and non-coding genes define hippocampal sclerosis in human temporal lobe epilepsy

Temporal lobe epilepsy is associated with large-scale, wide-ranging changes in gene expression in the hippocampus. Epigenetic changes to DNA are attractive mechanisms to explain the sustained hyperexcitability of chronic epilepsy. Here, through methylation analysis of all annotated C-phosphate-G isl...

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Vydáno v:Brain
Hlavní autoři: Miller-Delaney, Suzanne F.C., Bryan, Kenneth, Das, Sudipto, McKiernan, Ross C., Bray, Isabella M., Reynolds, James P., Gwinn, Ryder, Stallings, Raymond L., Henshall, David C.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2015
Témata:
Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4408428/
https://ncbi.nlm.nih.gov/pubmed/25552301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awu373
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