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BET bromodomain inhibition suppresses graft-versus-host disease after allogeneic bone marrow transplantation in mice
Acute graft-versus-host disease (GVHD) is the major obstacle of allogeneic bone marrow transplantation (BMT). Bromodomain and extra-terminal (BET) protein inhibitors selectively block acetyl-binding pockets of the bromodomains and modulate histone acetylation. Here, we report that inhibition of BET...
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Publicado no: | Blood |
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Main Authors: | , , , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
American Society of Hematology
2015
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4408296/ https://ncbi.nlm.nih.gov/pubmed/25778533 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-08-598037 |
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