BET bromodomain inhibition suppresses graft-versus-host disease after allogeneic bone marrow transplantation in mice

Acute graft-versus-host disease (GVHD) is the major obstacle of allogeneic bone marrow transplantation (BMT). Bromodomain and extra-terminal (BET) protein inhibitors selectively block acetyl-binding pockets of the bromodomains and modulate histone acetylation. Here, we report that inhibition of BET...

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Dettagli Bibliografici
Pubblicato in:Blood
Autori principali: Sun, Yaping, Wang, Ying, Toubai, Tomomi, Oravecz-Wilson, Katherine, Liu, Chen, Mathewson, Nathan, Wu, Julia, Rossi, Corinne, Cummings, Emily, Wu, Depei, Wang, Shaomeng, Reddy, Pavan
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2015
Soggetti:
Transplantation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4408296/
https://ncbi.nlm.nih.gov/pubmed/25778533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-08-598037
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