Inhibition of Lapatinib-induced Kinome Reprogramming in ERBB2-positive Breast Cancer by Targeting BET Family Bromodomains

Therapeutics such as lapatinib that target ERBB2 often provide initial clinical benefit but resistance frequently develops. Adaptive responses leading to lapatinib resistance involve reprogramming of the kinome through reactivation of ERBB2/ERBB3 signaling and transcriptional upregulation and activa...

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Publicado no:Cell Rep
Main Authors: Stuhlmiller, Timothy J., Miller, Samantha M., Zawistowski, Jon S., Nakamura, Kazuhiro, Beltran, Adriana S., Duncan, James S., Angus, Steven P., Collins, Kyla A. L., Granger, Deborah A., Reuther, Rachel A., Graves, Lee M., Gomez, Shawn M., Kuan, Pei-Fen, Parker, Joel S., Chen, Xin, Sciaky, Noah, Carey, Lisa A., Earp, H. Shelton, Jin, Jian, Johnson, Gary L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4408261/
https://ncbi.nlm.nih.gov/pubmed/25865888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.03.037
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