GSK2801, a BAZ2/BRD9 bromodomain inhibitor, synergizes with BET inhibitors to induce apoptosis in triple-negative breast cancer.

Screening of an inhibitor library targeting kinases and epigenetic regulators identified several molecules having anti-proliferative synergy with BET bromodomain inhibitors (JQ1, OTX015) in triple-negative breast cancer (TNBC). GSK2801, an inhibitor of BAZ2A/B bromodomains, of the imitation switch c...

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Detalhes bibliográficos
Publicado no:Mol Cancer Res
Main Authors: Bevill, Samantha M., Olivares-Quintero, Jose F., Sciaky, Noah, Golitz, Brian T., Singh, Darshan, Beltran, Adriana S., Rashid, Naim U., Stuhlmiller, Timothy J., Hale, Andrew, Moorman, Nathaniel J., Santos, Charlene M., Angus, Steven P., Zawistowski, Jon S., Johnson, Gary L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6610760/
https://ncbi.nlm.nih.gov/pubmed/31000582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-18-1121
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