Synthesis of Morphinan Alkaloids in Saccharomyces cerevisiae

Morphinan alkaloids are the most powerful narcotic analgesics currently used to treat moderate to severe and chronic pain. The feasibility of morphinan synthesis in recombinant Saccharomyces cerevisiae starting from the precursor (R,S)-norlaudanosoline was investigated. Chiral analysis of the reticu...

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Udgivet i:PLoS One
Main Authors: Fossati, Elena, Narcross, Lauren, Ekins, Andrew, Falgueyret, Jean-Pierre, Martin, Vincent J. J.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4408053/
https://ncbi.nlm.nih.gov/pubmed/25905794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0124459
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