Sixty-Five Common Genetic Variants and Prediction of Type 2 Diabetes

We developed a 65 type 2 diabetes (T2D) variant–weighted gene score to examine the impact on T2D risk assessment in a U.K.-based consortium of prospective studies, with subjects initially free from T2D (N = 13,294; 37.3% women; mean age 58.5 [38–99] years). We compared the performance of the gene sc...

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Pubblicato in:Diabetes
Autori principali: Talmud, Philippa J., Cooper, Jackie A., Morris, Richard W., Dudbridge, Frank, Shah, Tina, Engmann, Jorgen, Dale, Caroline, White, Jon, McLachlan, Stela, Zabaneh, Delilah, Wong, Andrew, Ong, Ken K., Gaunt, Tom, Holmes, Michael V., Lawlor, Debbie A., Richards, Marcus, Hardy, Rebecca, Kuh, Diana, Wareham, Nicholas, Langenberg, Claudia, Ben-Shlomo, Yoav, Wannamethee, S. Goya, Strachan, Mark W.J., Kumari, Meena, Whittaker, John C., Drenos, Fotios, Kivimaki, Mika, Hingorani, Aroon D., Price, Jacqueline F., Humphries, Steve E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Diabetes Association 2015
Soggetti:
Genetics/Genomes/Proteomics/Metabolomics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4407866/
https://ncbi.nlm.nih.gov/pubmed/25475436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db14-1504
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