Fully Human Monoclonal Antibody Inhibitors of the Neonatal Fc Receptor Reduce Circulating IgG in Non-Human Primates

The therapeutic management of antibody-mediated autoimmune disease typically involves immunosuppressant and immunomodulatory strategies. However, perturbing the fundamental role of the neonatal Fc receptor (FcRn) in salvaging IgG from lysosomal degradation provides a novel approach – depleting the b...

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Publicado no:Front Immunol
Main Authors: Nixon, Andrew E., Chen, Jie, Sexton, Daniel J., Muruganandam, Arumugam, Bitonti, Alan J., Dumont, Jennifer, Viswanathan, Malini, Martik, Diana, Wassaf, Dina, Mezo, Adam, Wood, Clive R., Biedenkapp, Joseph C., TenHoor, Chris
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2015
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4407741/
https://ncbi.nlm.nih.gov/pubmed/25954273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2015.00176
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