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Comparison of Nonlinear Mixed Effects Models and Noncompartmental Approaches in Detecting Pharmacogenetic Covariates

Genetic data is now collected in many clinical trials, especially in population pharmacokinetic studies. There is no consensus on methods to test the association between pharmacokinetics and genetic covariates. We performed a simulation study inspired by real clinical trials, using the pharmacokinet...

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書目詳細資料
發表在:AAPS J
Main Authors: Tessier, Adrien, Bertrand, Julie, Chenel, Marylore, Comets, Emmanuelle
格式: Artigo
語言:Inglês
出版: Springer US 2015
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4406951/
https://ncbi.nlm.nih.gov/pubmed/25693489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-015-9726-8
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