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Comparison of Nonlinear Mixed Effects Models and Noncompartmental Approaches in Detecting Pharmacogenetic Covariates

Genetic data is now collected in many clinical trials, especially in population pharmacokinetic studies. There is no consensus on methods to test the association between pharmacokinetics and genetic covariates. We performed a simulation study inspired by real clinical trials, using the pharmacokinet...

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Podrobná bibliografie
Vydáno v:AAPS J
Hlavní autoři: Tessier, Adrien, Bertrand, Julie, Chenel, Marylore, Comets, Emmanuelle
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer US 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4406951/
https://ncbi.nlm.nih.gov/pubmed/25693489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-015-9726-8
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