Systems Biology with High-Throughput Sequencing Reveals Genetic Mechanisms Underlying the Metabolic Syndrome in the Lyon Hypertensive Rat

BACKGROUND: The metabolic syndrome (MetS) is a collection of co-occurring complex disorders including obesity, hypertension, dyslipidemia, and insulin resistance. The Lyon Hypertensive (LH) and Lyon Normotensive (LN) rats are models of MetS sensitivity and resistance, respectively. To identify genet...

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Bibliographic Details
Published in:Circ Cardiovasc Genet
Main Authors: Wang, Jinkai, Ma, Man Chun John, Mennie, Amanda K., Pettus, Janette M., Xu, Yang, Lin, Lan, Traxler, Matthew G., Jakoubek, Jessica, Atanur, Santosh S., Aitman, Timothy J., Xing, Yi, Kwitek, Anne E.
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4406788/
https://ncbi.nlm.nih.gov/pubmed/25573024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGENETICS.114.000520
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