Chronic alcohol-induced hepatic insulin resistance and ER stress ameliorated by PPAR-δ agonist treatment

BACKGROUND: Chronic alcoholic liver disease is associated with hepatic insulin resistance, dysregulated lipid metabolism with increased toxic lipid (ceramide) accumulation, lipid peroxidation, and oxidative and endoplasmic reticulum (ER) stress. Peroxisome-proliferator activated receptor (PPAR) agon...

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Udgivet i:J Gastroenterol Hepatol
Main Authors: Ramirez, Teresa, Tong, Ming, Cy Chen, William, Nguyen, Quynh-Giao, Wands, Jack R., de la Monte, Suzanne M.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4406771/
https://ncbi.nlm.nih.gov/pubmed/22988930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1440-1746.2012.07256.x
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