Oncogenic NRAS Primes Primary Acute Myeloid Leukemia Cells for Differentiation

RAS mutations are frequently found among acute myeloid leukemia patients (AML), generating a constitutively active signaling protein changing cellular proliferation, differentiation and apoptosis. We have previously shown that treatment of AML patients with high-dose cytarabine is preferentially ben...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Brendel, Cornelia, Teichler, Sabine, Millahn, Axel, Stiewe, Thorsten, Krause, Michael, Stabla, Kathleen, Ross, Petra, Huynh, Minh, Illmer, Thomas, Mernberger, Marco, Barckhausen, Christina, Neubauer, Andreas
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4406710/
https://ncbi.nlm.nih.gov/pubmed/25901794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0123181
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