Oncogenic RAS Enables DNA Damage- and p53-Dependent Differentiation of Acute Myeloid Leukemia Cells in Response to Chemotherapy

Acute myeloid leukemia (AML) is a clonal disease originating from myeloid progenitor cells with a heterogeneous genetic background. High-dose cytarabine is used as the standard consolidation chemotherapy. Oncogenic RAS mutations are frequently observed in AML, and are associated with beneficial resp...

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Detalhes bibliográficos
Main Authors: Meyer, Mona, Rübsamen, Daniela, Slany, Robert, Illmer, Thomas, Stabla, Kathleen, Roth, Petra, Stiewe, Thorsten, Eilers, Martin, Neubauer, Andreas
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2767509/
https://ncbi.nlm.nih.gov/pubmed/19890398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007768
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