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Regulation of T cell development by c-Cbl: essential role of Lck

A canonical pre-TCR/TCR signaling pathway critical for thymic T cell development involves sequential phosphorylation and signaling through Lck, Zap70, Lat and Slp76. However, we and others have previously reported that genomic deletion of c-Cbl (Cbl) partially or completely reverses the defects in t...

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Bibliographic Details
Published in:Int Immunol
Main Authors: Chiang, Y. Jeffrey, Hodes, Richard J.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4406264/
https://ncbi.nlm.nih.gov/pubmed/25477210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/intimm/dxu105
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