Exposure to Endocrine Disruptor Induces Transgenerational Epigenetic Deregulation of MicroRNAs in Primordial Germ Cells

In mammals, germ cell differentiation is initiated in the Primordial Germ Cells (PGCs) during fetal development. Prenatal exposure to environmental toxicants such as endocrine disruptors may alter PGC differentiation, development of the male germline and induce transgenerational epigenetic disorders...

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Bibliographic Details
Published in:PLoS One
Main Authors: Brieño-Enríquez, Miguel A., García-López, Jesús, Cárdenas, David B., Guibert, Sylvain, Cleroux, Elouan, Děd, Lukas, Hourcade, Juan de Dios, Pěknicová, Jana, Weber, Michael, del Mazo, Jesús
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4405367/
https://ncbi.nlm.nih.gov/pubmed/25897752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0124296
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