Exposure to Endocrine Disruptor Induces Transgenerational Epigenetic Deregulation of MicroRNAs in Primordial Germ Cells

In mammals, germ cell differentiation is initiated in the Primordial Germ Cells (PGCs) during fetal development. Prenatal exposure to environmental toxicants such as endocrine disruptors may alter PGC differentiation, development of the male germline and induce transgenerational epigenetic disorders...

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Publicado en:PLoS One
Autores principales: Brieño-Enríquez, Miguel A., García-López, Jesús, Cárdenas, David B., Guibert, Sylvain, Cleroux, Elouan, Děd, Lukas, Hourcade, Juan de Dios, Pěknicová, Jana, Weber, Michael, del Mazo, Jesús
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4405367/
https://ncbi.nlm.nih.gov/pubmed/25897752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0124296
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