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Modulation of the Disordered Conformational Ensembles of the p53 Transactivation Domain by Cancer-Associated Mutations

Intrinsically disordered proteins (IDPs) are frequently associated with human diseases such as cancers, and about one-fourth of disease-associated missense mutations have been mapped into predicted disordered regions. Understanding how these mutations affect the structure-function relationship of ID...

詳細記述

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書誌詳細
出版年:PLoS Comput Biol
主要な著者: Ganguly, Debabani, Chen, Jianhan
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4405366/
https://ncbi.nlm.nih.gov/pubmed/25897952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004247
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