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Residual Structures, Conformational Fluctuations, and Electrostatic Interactions in the Synergistic Folding of Two Intrinsically Disordered Proteins

To understand the interplay of residual structures and conformational fluctuations in the interaction of intrinsically disordered proteins (IDPs), we first combined implicit solvent and replica exchange sampling to calculate atomistic disordered ensembles of the nuclear co-activator binding domain (...

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Autori principali: Zhang, Weihong, Ganguly, Debabani, Chen, Jianhan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3257294/
https://ncbi.nlm.nih.gov/pubmed/22253588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002353
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