A Genome-Wide Map of AAV-Mediated Human Gene Targeting

To determine which genomic features promote homologous recombination, we created a genome-wide map of gene targeting sites. An adeno-associated virus vector was used to target identical loci introduced as transcriptionally active retroviral vector proviruses. A comparison of ~2,000 targeted and unta...

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Vydáno v:Nat Struct Mol Biol
Hlavní autoři: Deyle, David R., Hansen, R. Scott, Cornea, Anda M., Li, Li B., Burt, Amber A., Alexander, Ian E., Sandstrom, Richard S., Stamatoyannopoulos, John A., Wei, Chia-Lin, Russell, David W.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4405182/
https://ncbi.nlm.nih.gov/pubmed/25282150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2895
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