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A molecular framework for temperature-dependent gating of ion channels

Perception of heat or cold in higher organisms is mediated by specialized ion channels whose gating is exquisitely sensitive to temperature. The physicochemical underpinnings of this temperature-sensitive gating have proven difficult to parse. Here, we took a bottom-up protein design approach, and r...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Chowdhury, Sandipan, Jarecki, Brian W., Chanda, Baron
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4405168/
https://ncbi.nlm.nih.gov/pubmed/25156949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.07.026
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