A New Pyrimidine-Specific Reporter Gene: A Mutated Human Deoxycytidine Kinase Suitable for PET During Treatment with Acycloguanosine-Based Cytotoxic Drugs

In this article, we describe a series of new human-derived reporter genes based on human deoxycytidine kinase (dCK) suitable for clinical PET. METHODS: Native dCK and its mutant reporter genes were tested in vitro and in vivo for their phosphorylation of pyrimidine- and acycloguanosine-based radiotr...

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Publicado en:J Nucl Med
Main Authors: Likar, Yury, Zurita, Juan, Dobrenkov, Konstantin, Shenker, Larissa, Cai, Shangde, Neschadim, Anton, Medin, Jeffrey A., Sadelain, Michel, Hricak, Hedvig, Ponomarev, Vladimir
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4405132/
https://ncbi.nlm.nih.gov/pubmed/20810757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.109.074344
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