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Oncolytic virus expressing RANTES and IL-15 enhances function of CAR-modified T cells in solid tumors

We improved the migration and survival of chimeric antigen receptor (CAR)-modified T cells in solid tumors by combining CAR-T cells with an armed oncolytic virus. Local delivery of the chemokine RANTES and the cytokine IL-15 by the oncolytic virus enhanced the trafficking and persistence of the CAR-...

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Bibliografske podrobnosti
izdano v:Oncoimmunology
Main Authors: Nishio, Nobuhiro, Dotti, Gianpietro
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4404887/
https://ncbi.nlm.nih.gov/pubmed/25949885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/21505594.2014.988098
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