Indoleamine-2,3-dioxygenase (IDO) metabolic activity is detrimental for cervical cancer patient survival

The expression of the immunomodulating enzyme indoleamine-2,3-dioxygenase (IDO) suppresses T-lymphocyte function, thus correlating with poor survival in a variety of cancer patients. IDO degrades the essential amino acid tryptophan leading to immunosuppressive kynurenines production. In the present...

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Bibliografiske detaljer
Udgivet i:Oncoimmunology
Main Authors: Ferns, Debbie M, Kema, Ido P, Buist, Marrije R, Nijman, Hans W, Kenter, Gemma G, Jordanova, Ekaterina S
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2015
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4404792/
https://ncbi.nlm.nih.gov/pubmed/25949879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/2162402X.2014.981457
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