Therapeutic targeting of CBP/β-catenin signaling reduces cancer stem-like population and synergistically suppresses growth of EBV-positive nasopharyngeal carcinoma cells with cisplatin

Nasopharyngeal carcinoma (NPC) is an EBV-associated epithelial malignancy prevalent in southern China. Presence of treatment-resistant cancer stem cells (CSC) may associate with tumor relapse and metastasis in NPC. ICG-001 is a specific CBP/β-catenin antagonist that can block CBP/β-catenin-mediated...

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Publicado no:Sci Rep
Main Authors: Chan, King Chi, Chan, Lai Sheung, Ip, Joseph Chok Yan, Lo, Carman, Yip, Timothy Tak Chun, Ngan, Roger Kai Cheong, Wong, Ricky Ngok Shun, Lo, Kwok Wai, Ng, Wai Tong, Lee, Anne Wing Mui, Tsao, George Sai Wah, Kahn, Michael, Lung, Maria Li, Mak, Nai Ki
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4404684/
https://ncbi.nlm.nih.gov/pubmed/25897700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep09979
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