Therapeutic targeting of CBP/β-catenin signaling reduces cancer stem-like population and synergistically suppresses growth of EBV-positive nasopharyngeal carcinoma cells with cisplatin

Nasopharyngeal carcinoma (NPC) is an EBV-associated epithelial malignancy prevalent in southern China. Presence of treatment-resistant cancer stem cells (CSC) may associate with tumor relapse and metastasis in NPC. ICG-001 is a specific CBP/β-catenin antagonist that can block CBP/β-catenin-mediated...

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Bibliografiset tiedot
Julkaisussa:Sci Rep
Päätekijät: Chan, King Chi, Chan, Lai Sheung, Ip, Joseph Chok Yan, Lo, Carman, Yip, Timothy Tak Chun, Ngan, Roger Kai Cheong, Wong, Ricky Ngok Shun, Lo, Kwok Wai, Ng, Wai Tong, Lee, Anne Wing Mui, Tsao, George Sai Wah, Kahn, Michael, Lung, Maria Li, Mak, Nai Ki
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2015
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4404684/
https://ncbi.nlm.nih.gov/pubmed/25897700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep09979
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