Regulation of autophagy and the ubiquitin–proteasome system by the FoxO transcriptional network during muscle atrophy

Stresses like low nutrients, systemic inflammation, cancer or infections provoke a catabolic state characterized by enhanced muscle proteolysis and amino acid release to sustain liver gluconeogenesis and tissue protein synthesis. These conditions activate the family of Forkhead Box (Fox) O transcrip...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Milan, Giulia, Romanello, Vanina, Pescatore, Francesca, Armani, Andrea, Paik, Ji-Hye, Frasson, Laura, Seydel, Anke, Zhao, Jinghui, Abraham, Reimar, Goldberg, Alfred L., Blaauw, Bert, DePinho, Ronald A., Sandri, Marco
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Pub. Group 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4403316/
https://ncbi.nlm.nih.gov/pubmed/25858807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7670
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