Making water-soluble integral membrane proteins in vivo using an amphipathic protein fusion strategy

Integral membrane proteins (IMPs) play crucial roles in all cells and represent attractive pharmacological targets. However, functional and structural studies of IMPs are hindered by their hydrophobic nature and the fact that they are generally unstable following extraction from their native membran...

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Vydáno v:Nat Commun
Hlavní autoři: Mizrachi, Dario, Chen, Yujie, Liu, Jiayan, Peng, Hwei-Ming, Ke, Ailong, Pollack, Lois, Turner, Raymond J., Auchus, Richard J., DeLisa, Matthew P.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Pub. Group 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4403311/
https://ncbi.nlm.nih.gov/pubmed/25851941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7826
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